Kariega Game Reserve-Settlers Drift is located in a remote wilderness area near Bushmans River, close to Grahamstown in South Africa's Eastern Cape. The lodge is set within the 11,500-hectare Kariega Game Reserve, known for its diverse wildlife and scenic river views. It lies about 50 km from Port Elizabeth and 30 km from historic Grahamstown. The nearest major airport is Gqeberha (Port Elizabeth) Airport, approximately 130 km from the lodge.