Mardin Osmanli Konagi is located in the historic Merkez district of Mardin, known for its rich cultural heritage and stone architecture. The hotel is within walking distance of landmarks such as Sehidiye Mosque and Sabanci City Museum, about 5 km from Zinciriye Medresesi, and 0.7 km from Melik Mahmut Mosque. Mardin Airport is approximately 20 km from the hotel.