Antelar Casa Destino is located in the historic Centro district of Mérida, known for its vibrant cultural scene and colonial architecture. The hotel is within walking distance of landmarks such as Paseo de Montejo and Mérida Cathedral, both about 1.5 km away. The U.S. Consulate and Yucatán International Convention Center are approximately 2.6 km and 3 km from the hotel, respectively. Mérida International Airport is 10 km from the property.