Domus Romana is located in the Monti neighborhood of Rome, a historic area known for its charming streets and vibrant atmosphere. The hotel is just minutes from Via Condotti, with landmarks such as the Pantheon about 1.2 km away and Piazza Venezia approximately 1.5 km distant. Rome's Ciampino Airport is 13 km from the hotel, while Fiumicino Airport is 23 km away.