La Casona De Tita Oaxaca is located in the historic Centro neighborhood of Oaxaca City, known for its rich cultural heritage and colonial architecture. The hotel is within walking distance of key landmarks such as the Santo Domingo Church (about 0.4 km), the Museo de las Culturas de Oaxaca (0.4 km), and the Rufino Tamayo Museum (0.8 km). Oaxaca Xoxocotlán International Airport is approximately 7.5 km from the hotel.