Villa Matissa is located in the Trastevere neighborhood of Rome, a charming area known for its vibrant nightlife and historic streets. The hotel is just a short walk from Piazza di Santa Maria in Trastevere (about 0.6 km) and Campo de' Fiori (approximately 1.4 km). The Roman Forum is also nearby, around 1.9 km away. Rome Ciampino Airport is 16 km from the hotel, while Rome Fiumicino Airport is about 30 km away.